Psychiatric Drug Reactions and Interactions

EBook Description: Book author: Jerome Z. Litt

Book author: Frederick T. Fraunfelder

The Renal Drug Handbook Book

Book author: Aileen Currie and Caroline Ashley

Pharmacology and Vitreoretinal Surgery Developments in Ophthalmology

Book author: Arnd Gandorfer

Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book

Within the pharmaceutical industry, the mass spectrometer was long considered a useful and challenging analytical tool largely limited to the specialist user. The steady movement from specialist use to general use gained considerable speed in the 1990s, particularly due to the development of practical, sensitive liquid chromatography�mass spectrometry (LC�MS) interfaces and advances in the microelectronics. The rapid proliferation of quadrupole ion trap, linear ion trap, orbitrap, quadrupole mass filter, time-of-flight, and other types of mass spectrometers has impacted the industry from the earliest stages of disease determination through the final stages of clinical testing. This book, based on an American Society for Mass Spectrometry (ASMS) session, which I was fortunate enough to chair, will examine several of the ways in which mass spectrometry continues to have a profound influence on the direction and speed of drug discovery and development, especially in the area of drug metabolism (DM) and pharmacokinetics (PK).

Applied Therapeutics: The Clinical Use of Drugs Book

In a case approach, the ninth edition of Applied Therapeutics: The clinical use of drugs to students the fundamentals of drug therapeutics allows to master. All contributions are leading clinicians with many years of evidence-based care. As students will progress through the text, they learn the basics of common diseases and disorders and practical problem-solving skills for devising and implementing successful drug treatment regimens. "Doody's Core Title � 2009."

Lippincott's Illustrated Reviews: Pharmacology, 4th Edition Book

Lippincott's Illustrated Reviews: Pharmacology, Fourth Edition enables rapid review and adjustment of large amounts of complex information on the fundamentals of medical pharmacology. Clear, sequential pictures of mechanisms of action actually show students how drugs work, instead of just to say it. As in previous editions, the book provides an overview answer format, over 500 color illustrations, cross-references to other volumes of the series, and over 125 review questions. Content has been thoroughly updated and includes a new chapter in toxicology. New in this edition is a companion Web site with all images, fully searchable text and an interactive question bank. Note: International Edition for sales outside of North America and the Caribbean (ISBN: 978-1-60547-200-3), "Doody's Core Title � 2009."

Drug-Drug Interaction Primer: A Compendium of Case Vignettes for the Practicing Clinician Book

This user-friendly resource offers complete and comprehensive coverage of the difficult challenges of drug-drug interactions arise. More than 170 cases a variety of interactions (DDI) to show an unintimidating even entertaining way to understanding these issues. Drug interaction studies Primer builds on earlier work by the author, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features references throughout and 29 new cases that such clinical examples of how a patient with schizoaffective disorder transitions of haloperidol, aripiprazole diagnosed with offer devastating consequences, an AIDS patient with trimethoprim-sulfamethoxazole replace warfarin following atrial fibrillation, which returned to ischemic stroke, and a delusional patient on risperidone Phenytoin is used in these attacks, and delusions. Previous cases have been revised to provide clarity.

Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition PDF Book

Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and in particular, antisense therapy and research. Interpretation Lessons from the clinical trials of first-generation drugs studied, the book evaluates the technology as a whole and offers new directions and ways of research and development. Structured in five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing path, and the possible treatment of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in the second part of the division of medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery.

Pharmaceutical Biotechnology: Concepts and Applications PDF Book

Pharmaceutical Biotechnology offers students, pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the rapidly developing field of biopharmaceuticals. Made with a special focus on the issue from a pharmaceutical perspective, offer the first chapter, a broad introduction to protein science and recombinant DNA technology-key areas that support the whole thing. Subsequent chapters focus on the development, production and analysis of these substances. Finally, moving the book on the science, biotechnology, and explore medical applications of specific biotech products categories. These include not only protein substances but also nucleic acid and cell count-based products.

Mass Spectrometry in Drug Metabolism and Pharmacokinetics Book

The first step in discovering a new medicine is to identify a therapeutic target. Drugs in today�s market as well as those in recent clinical testing target less than 500 biomolecules, with more than 10 times that many potential therapeutic targets waiting to be discovered and developed (Drews, 2000). More than 50% of the newly approved drugs result from R&D involving previously clinically tested and validated targets. Once a target has been validated (proven to be related to the disease process), high-throughput screening methods may be used to determine initial structural leads. Compounds are assessed for target affinity and for their �druglike� properties, including absorption, distribution, metabolism, and excretion (ADME) using a series of in vivo and in vitro tests. The results of these tests are used to improve the structure and therefore the properties of the next round of test compounds, until ultimately one or more acceptable compounds are advanced forward in the process. This stage of discovery, which can be lengthy and difficult to predict, is generally referred to as lead optimization.

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